Nambala ya Cas: 144701-48-4 Molecular Formula: C33H30N4O2

Kufotokozera Kwachidule:

Nambala ya Cas: 144701-48-4
Dzina la Chemical:
Molecular formula: C33H30N4O2

Mawu ofanana ndi mawu: MICARDIS;TU-199;Telmisaran;TIMISHATAN;2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1 ,3-benzodiazol-1-yl]Methyl}phenyl)benzoic acid;4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl ][1,1′-biphenyl]-2-carboxylic acid, BIBR 277;PRITOR;BIBR 277;misartan;BIBR 277SE

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Kufotokozera Kwazinthu

Melting Point	261-263 ° C
Kuchulukana	1.16 (kungoyerekeza)
kutentha kutentha	M'mlengalenga, Kutentha kwa Zipinda 2-8 ° C
kusungunuka	DMSO:> 5 mg/mL pa 60 °C
kuwala ntchito	N / A
Maonekedwe	Off-White Solid
Chiyero	≥98%

Kufotokozera

idakhazikitsidwa ku US pochiza matenda oopsa.Ikhoza kukonzedwa mu masitepe asanu ndi atatu kuyambira ndi methyl 4-amino-3-methyl benzoate;woyamba ndi wachiwiri cyclization mu mphete benzimidazole zimachitika pa masitepe 4 ndi 6 motero.imalepheretsa zochita za angiotensin II (Ang II), molekyulu yayikulu ya renin-angiotensin-aldosterone system (RAAS).Ndi gulu lachisanu ndi chimodzi la gulu ili la 《sartans》 kuti ligulitsidwe pambuyo pa mankhwala otsogolera a Losartan.Zotsatira zake zokhalitsa (24h theka la moyo) zitha kukhala kusiyana kwakukulu ndi ena otsutsa angiotensin II.Mosiyana ndi othandizira ena angapo omwe ali mgululi, zochita zake sizidalira kusinthika kukhala metabolite yogwira, 1-O-acylglucuronide kukhala metabolite yayikulu yomwe imapezeka mwa anthu. angiotensin II pomwe akusowa kuyanjana kwa ma AT2 subtypes kapena ma receptor ena omwe amakhudzidwa ndi kayendedwe ka mtima.M'maphunziro angapo azachipatala, mulingo umodzi watsiku ndi tsiku, umatulutsa zotsatira zogwira mtima komanso zokhazikika zochepetsera kuthamanga kwa magazi ndi kuchepa kwa zotsatirapo (makamaka chifuwa chokhudzana ndi chithandizo chomwe chimalumikizidwa ndi ACE inhibitors mwa okalamba).