Nambala ya Cas: 54-31-9 Molecular Formula: C12H11ClN2O5S

Telmisartan idakhazikitsidwa ku US pochiza matenda oopsa.Ikhoza kukonzedwa mu masitepe asanu ndi atatu kuyambira ndi methyl 4-amino-3-methyl benzoate;woyamba ndi wachiwiri cyclization mu mphete benzimidazole zimachitika pa masitepe 4 ndi 6 motero.Telmisartan imatsekereza zochita za angiotensin II (Ang II), molekyulu yayikulu ya renin-angiotensin-aldosterone system (RAAS).Ndi gulu lachisanu ndi chimodzi la gulu ili la 《sartans》 kuti ligulitsidwe pambuyo pa mankhwala otsogolera a Losartan.Zotsatira zake zokhalitsa (24h theka la moyo) zitha kukhala kusiyana kwakukulu ndi ena otsutsa angiotensin II.Mosiyana ndi othandizira ena angapo omwe ali mgululi, zochita zake sizidalira kusinthika kukhala metabolite yogwira, 1-O-acylglucuronide kukhala metabolite yayikulu yomwe imapezeka mwa anthu.Telmisartan ndi mdani wamphamvu wampikisano wa AT1 receptors omwe amayimira mbali zambiri zofunika za angiotensin II pomwe alibe mgwirizano wa AT2 subtypes kapena ma receptor ena omwe amakhudzidwa ndi dongosolo lamtima.M'maphunziro angapo azachipatala, Telmisartan, kamodzi patsiku, imatulutsa zotsatira zogwira mtima komanso zokhazikika zochepetsera kuthamanga kwa magazi ndi kuchepa kwa zotsatirapo (makamaka chifuwa chokhudzana ndi chithandizo chokhudzana ndi ACE inhibitors mwa okalamba).