Nambala ya Cas: 1115-70-4 Molecular Formula: C4H11N5

Zogulitsa

Nambala ya Cas: 1115-70-4 Molecular Formula: C4H11N5

Kufotokozera Kwachidule:

Nambala ya Cas: 1115-70-4
Dzina la Chemical:
Molecular formula: C4H11N5
Mawu ofanana: Hydrochloride, Glucophage, etc.


Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

tsatanetsatane wazinthu

Melting Point 233-236 ℃
Kuchulukana 1.48g/cm³
kutentha kutentha 15-30 ℃
kusungunuka Kusungunuka m'madzi, kusungunuka mu Mowa, komanso kusungunuka mu chloroform ndi benzene.
kuwala ntchito +25.7 madigiri (C=1, madzi)
Maonekedwe woyera crystalline ufa

mankhwala pharmacology

The molecular pharmacological limagwirira wa pakali pano si bwino kumvetsa.Amadziwika kuti amagwira ntchito pachiwindi, amachepetsa gluconeogenesis (mwachitsanzo, kupanga shuga) ndikuchepetsa kukana kwa insulin.Kafukufuku wina wasonyeza kuti amatha kuyambitsa AMP activated protein kinase (AMPK), yomwe ndi imodzi mwamakina ofunikira kuti aletse gluconeogenesis ya chiwindi ndikuwongolera chidwi cha insulin panjira yosinthira ma sign a insulin.AMPK, monga protein kinase, imagwira ntchito yofunikira osati pa njira yowonetsera insulin, komanso mu mphamvu zonse za mphamvu ndi shuga ndi mafuta a metabolism.Kuyesa kwa nyama ndi maphunziro azachipatala awonetsa kuti angapangitse kusintha kwakukulu pakupangidwa kwa fecal microbiota mu matenda a shuga, zomwe sizingangowonjezera kutulutsa ndi zotsatira za glucagon ngati peptide-1 (GLP-1), komanso kutsimikizira kukulitsa chidwi cha insulin. , yomwenso ndi imodzi mwamakina ofunikira kwambiri pakuwongolera matenda amtundu wa 2.

ntchito mankhwala

Mankhwalawa ayenera kugwiritsidwa ntchito pang'onopang'ono ndikuwonjezeka pang'onopang'ono malinga ndi momwe wodwalayo alili.Mlingo woyamba wa mankhwalawa (mapiritsi a hydrochloride) nthawi zambiri amakhala 0,5 magalamu, kawiri pa tsiku;Kapena 0,85 magalamu, kamodzi patsiku;Tengani ndi zakudya.

Kagwiritsidwe ndi Mlingo

Mankhwalawa ayenera kugwiritsidwa ntchito pang'onopang'ono ndikuwonjezeka pang'onopang'ono malinga ndi momwe wodwalayo alili.Mlingo woyamba wa mankhwalawa (mapiritsi a hydrochloride) nthawi zambiri amakhala 0,5 magalamu, kawiri pa tsiku;Kapena 0,85 magalamu, kamodzi patsiku;Tengani ndi zakudya.

Metformin

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