Nambala ya Cetilistat Cas: 282526-98-1 Molecular Formula:C25H39NO3
| Melting Point | 72.0 mpaka 76.0 °C |
| Kuchulukana | 1.02 |
| kutentha kutentha | Kusindikizidwa mu youma, 2-8 ° C |
| kusungunuka | Chloroform (Pang'ono), Ethyl Acetate (Pang'ono) |
| kuwala ntchito | N / A |
| Maonekedwe | Choyera-Cryst |
| Chiyero | ≥98% |
Cetilistat (yomwe imadziwikanso kuti ATL-962) idavomerezedwa mu Seputembara 2013 ndi Unduna wa Zaumoyo, Ntchito ndi Zaumoyo ku Japan pochiza kunenepa kwambiri, kwa odwala omwe ali ndi matenda amtundu wa 2 shuga mellitus (T2DM) ndi dyslipidemia, komanso okhala ndi thupi. index (BMI) 25 kg/m2mosasamala kanthu za chithandizo chamankhwala ndi/kapena kuchita masewera olimbitsa thupi.Monga orlistat, cetilistat imagwira ntchito poletsa pancreatic lipases m'matumbo kuti aletse kuyamwa kwamafuta ndikuchepetsa kutengeka kwa calorie kuchokera kuzakudya.Dongosolo la chemistry yamankhwala silinafotokozedwe m'mabuku asayansi, koma patent yofotokoza cetilistat imafotokozeranso kaphatikizidwe ka ma analogi okhala ndi ma aryl substituents osiyanasiyana komanso michira ya lipophilic.Kaphatikizidwe ka cetilistat kumaphatikizapo condensation ya hexadecylcarbonochloridate ndi 2-amino-5-methylbenzoic acid;ma analogi ena adapangidwa ndi kusiyanasiyana kwa carbonochloridate ndi 2-aminobenzoic acid zigawo.Cetilistat ndi inhibitor yamphamvu ya anthu ndi makoswe pancreatic lipase yokhala ndi IC50sya 15 ndi 136 nM, motsatana, ndi kuletsa pang'ono kwa trypsin kapena chymotrypsin.
Novel pancreatic lipase inhibitor yochizira kunenepa kwambiri kwa odwala matenda ashuga komanso omwe alibe matenda a shuga.
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