Nambala ya Cas: 224785-91-5 Molecular Formula:C23H33ClN6O4S

Kufotokozera Kwachidule:

Nambala ya Cas: 224785-91-5

Dzina la Chemical:

Molecular Formula:Chithunzi cha C23H33ClN6O4S

Masinonimu: HCL;Vardenafi;Nuviva;fafinafei;Valdenafil;Levitra, Valdenafil;USP/EP/BP;Levitra,Valdenafil.HCl;224785-91-5;

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Kufotokozera Kwazinthu

Melting Point	214-216 ° C
Kuchulukana	N / A
kutentha kutentha	M'nyengo yozizira, 2-8 ° C
kusungunuka	N / A
kuwala ntchito	N / A
Maonekedwe	White mpaka Off-White Cyrstalline
Chiyero	≥98%

pharmacodynamics

anali wothandizira wachiwiri kuti agulitsidwe ndipo anali ndi mwayi woti nthawi yake yoyamba sinachepetsedwe ndi kumwa mankhwala pamimba yodzaza .Ndi nthawi 30 yamphamvu kwambiri ngati inhibitor ya PDE5 (kutanthauza IC50, 3.9 nM) kuposa sildenafil ndi nthawi 10 yamphamvu kuposa tadalafil, ndi kusankha kwakukulu (> 1,000 nthawi) kwa PDE5 yaumunthu kusiyana ndi PDE2, PDE3, ndi PDE4 yaumunthu ndi kusankha kwapakati (> 80 nthawi) kwa PDE1.PDE inhibitory selectivity komanso in vitro ndi vivo potency ya PDE5 inhibitor yatsopano.makamaka inaletsa hydrolysis ya cGMP ndi PDE5, ndi IC50 ya 0.7 nM (sildenafil 6.6 nM).IC50 ya PDE1 inali 180 nM, ya PDE6 11 nM, ndi PDE2, PDE3 ndi PDE4 kuposa 1,000 nM.