Nambala ya Rifampicin Cas: 13292-46-1 Molecular Formula: C43H58N4O12

Rifampicin ndi semisynthetic yochokera ku rifamicin B, macrolactam antibiotic ndi imodzi mwa maantibayotiki opitilira asanu osakanikirana ndi rifamicins A, B, C, D, ndi E, omwe amatchedwa rifamicin complex, omwe amapangidwa ndi actinomycetes Streptomyces mediteranei ( Nocardia mediteranei).Idayambitsidwa muzachipatala mu 1968. Kaphatikizidwe ka rifampicin kumayamba ndi njira yamadzimadzi ya rifamicin, yomwe imapangidwa ndi oxidized kukhala chotumphukira chatsopano cha rifamicin S (32.7.4), ndikupangidwa kwapakatikati kwa rifamicin O (32.7. 3).Kuchepetsa mawonekedwe a quinone a mankhwalawa ndi haidrojeni pogwiritsa ntchito palladium pa carbon catalyst kumapereka rifamicin SV (32.7.5).Zotsatira zake zimakhala ndi aminomethylation ndi chisakanizo cha formaldehyde ndi pyrrolidine, kupereka 3-pyrrolidinomethylrifamicin SV (32.7.6).Kuphatikizika kwa mankhwalawa ndi tetracetate ya lead kupita ku enamine ndi hydrolysis yotsatizana ndi njira yamadzi ya ascorbic acid kumapereka 3-formylrifamicin SV (32.7.7).Kuchita izi ndi 1-amino-4-methylpiperazine kumapereka rifampicin (32.7.8).