Nambala ya Cas: 330784-47-9 Molecular Formula: C23H26ClN7O3

Kufotokozera Kwachidule:

Nambala ya Cas: 330784-47-9

Dzina la Chemical:

Molecular formula: C23H26ClN7O3

Mawu ofanana ndi mawu:(S) -2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine

4 - [(3-Chloro-4-methoxybenzyl) amino] -2--[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl) -5-pyrimidinecarboxamide

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Kufotokozera Kwazinthu

Melting Point	150-152 ° C
Kuchulukana	1.372
kutentha kutentha	Osindikizidwa muumirira, Sungani mufiriji, pansi pa -20°C
kusungunuka	DMSO (Pang'ono), Methanol (Pang'ono, Kutentha)
kuwala ntchito	N / A
Maonekedwe	White mpaka Off-White
Chiyero	≥98%

pharmacodynamics

(Zepeed) idavomerezedwa ndi Unduna wa Zaumoyo ku Korea kuti athe kuchiza erectile dysfunction (ED) mu Ogasiti 2011.ndi mtundu wosankha kwambiri wa 5 phosphodiesterase (PDE5) inhibitor.akuti ndiye PDE5 inhibitor yosankha kwambiri pamsika.Kuyamba kwa Tmax ndi theka la moyo kumasiyananso pakati pa PDE5 inhibitors omwe amagulitsidwa.Sildenafil ali ndi T_maxpa 1 h ndi theka moyo wa 3-5 h.Vardenafil ndi ofanana ndi T_maxwa 0.6 h ndi theka moyo wa 4-6 h.Tadalafil ali ndi theka lalitali kwambiri pakati pa mankhwala ogulitsidwa ndi theka la moyo wa 17 h.imayamba mwachangu kufika ku T_maxmu 0,6 h ndi theka la moyo wa 1.2 h.Kuphatikizika kwa (TA-1790) kumafotokozedwa m'mabuku a patent.Njira yayikulu yochotsera ndi kudzera mu ndulu ndi ndowe.Anapezekanso kuti amalowetsedwanso kudzera mu enterohepatic recirculation.