Nambala ya Cas: 147403-03-0 Molecular Formula: C24H29N5O3
| Melting Point | 230 ° C |
| Kuchulukana | 1.41g/cm³ |
| kutentha kutentha | 2-8 ℃ |
| kusungunuka | Ndi pafupifupi osasungunuka m'madzi, ndipo kusungunuka kwa ethanol ndi 5.5 mg/m |
| kuwala ntchito | +76.5 madigiri (C=1, ethanol) |
| Maonekedwe | zoyera kapena zoyera zolimba, zopanda fungo |
Ndiwopanda peptide, wothandizira pakamwa angiotensin II (AT) receptor antagonist.Ili ndi kusankha kwakukulu kwa mtundu wa I receptor (AT1) ndipo imatha kupikisana nawo popanda zotsatira zolimbikitsa.Itha kuletsanso kutulutsidwa kwa AT1 receptor mediated aldosterol kuchokera ku ma adrenal glomerular cell, koma ilibe choletsa pakutulutsidwa kwa potaziyamu, zomwe zikuwonetsa kusankhidwa kwake pama receptors a AT1.Kuyesera mu vivo pamitundu yosiyanasiyana ya nyama zothamanga kwambiri kwawonetsa kuti ili ndi zotsatira zabwino za antihypertensive ndipo ilibe mphamvu yayikulu pakugwira ntchito kwa mtima wa contractile ndi kugunda kwa mtima.Palibe antihypertensive kwambiri nyama ndi yachibadwa magazi
Mankhwala a antihypertensive.ndi mdani wa angiotensin II (Ang II) receptor omwe amaletsa mwasankha kumangirira kwa Ang II ku AT1 zolandilira (zotsatira zake zotsutsana ndi AT1 zolandilira zimakhala pafupifupi nthawi 20000 kuposa za AT2), motero zimalepheretsa kutsika kwa mitsempha ndi kutulutsidwa kwa aldosterone, zomwe zimapangitsa hypotensive zotsatira
Mlingo woyambira wamapiritsi ndi 80mg (mapiritsi awiri), amatengedwa pakamwa kamodzi patsiku.Nthawi zambiri, ngati sichikugwira ntchito kwa masabata a 4, mlingo ukhoza kuwonjezeka kufika pa 160mg (mapiritsi anayi) kamodzi patsiku.Malinga ndi kafukufuku wazachipatala wakunja, mlingo waukulu ukhoza kufika 320mg (mapiritsi 8) kamodzi patsiku
1. Odwala omwe ali ndi matenda oopsa kwambiri omwe ali ndi matenda a shuga, matenda oopsa omwe amakhala ndi nephropathy kapena matenda a shuga nephropathy,
2.odwala matenda oopsa kwambiri zovuta mtima kulephera kapena myocardial infarction
