l Nambala ya Cas: 171596-29-5 Molecular Formula: C₂₂H₁₉N₃O₄
| Melting Point | > 193 ° C |
| Kuchulukana | DMF: 25 mg/ml DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml DMSO: 20 mg/ml |
| kutentha kutentha | -20 ° C |
| kusungunuka | DMF: 25 mg/ml DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml DMSO: 20 mg/ml |
| kuwala ntchito | [α]/D +68 mpaka +78°, c = 1 mu chloroform-d |
| Maonekedwe | Choyera mpaka Choyera Cholimba |
| Chiyero | ≥98% |
(dzina la msika kapena ) ndi mtundu wa PDE5 inhibitor womwe umagwiritsidwa ntchito pochiza erectile dysfunction, benign prostatic hypertrophy ndi pulmonary arterial hypertension.Zotsatira zake ndikupumula minofu ya mitsempha yamagazi ndikuwonjezera kutuluka kwa magazi mu corpus cavernosum.Njira yochitira ndi kuletsa ntchito ya cGMP yeniyeni ya phosphodiesterase mtundu 5 (PDE5).PDE5 imawononga cGMP mu corpus cavernosum yomwe ili mozungulira mbolo.Chifukwa chake, tadalafi imatsogolera pakuchulukirachulukira kwa cGMP komwe kumapangitsanso kupumula kwa minofu ndikuwonjezera magazi kulowa mu corpus cavernosum.Kafukufuku wina wachipatala adawonetsanso kuti atha kusintha magwiridwe antchito a endothelia mwa amuna omwe ali ndi chiopsezo chowonjezereka cha mtima komanso kutsitsa zizindikiro za mkodzo wachiwiri kukhala benign prostatic hyperplasia.
analgesic, uptake blocker, mu-opiod receptor agonist.Phosphodiesterase 5 inhibitor.amagwiritsidwa ntchito pochiza vuto la erectile.
ndi yosiyana ndi kapangidwe ka sildenafil ndi vardenafil.Imayamwa mwachangu ndikufika pachimake (378 μg/L pambuyo pa mlingo wa 20-mg) pambuyo pa maola awiri, kuwonetsa theka la moyo wautali wa maola 17.5.Imapangidwanso ndi chiwindi (CYP3A4).Makamaka, ma pharmacokinetics ake samakhudzidwa ndi mowa kapena kudya kapena zinthu monga matenda a shuga kapena kulephera kwa chiwindi kapena aimpso.
