Nambala ya Cas: 146-56-5 Molecular Formula: C20H21ClN2O4
| Melting Point | 176-178 ° C |
| Kuchulukana | 1.02g/cm³ |
| kutentha kutentha | anang'ambika ndi kutentha kwa chipinda, kunja kwa dzuwa ndi m'malo achinyezi |
| kusungunuka | 50 mg/ml (Mu Mowa);Zosasungunuka m'madzi |
| kuwala ntchito | +111.6 madigiri (C=1, methanol) |
| Maonekedwe | woyera kapena pafupifupi woyera crystalline ufa |
| Chiyero | ≥97% |
ndi "dihydropyridine calcium antagonist" (calcium antagonist, kapena slow channel blocker) yomwe imalepheretsa kuyenda kwa "calcium ions" kupita ku maselo osalala a minofu ndi myocyte wamtima.Deta yoyesera imasonyeza kuti imagwirizanitsidwa ndi "malo omangiriza" a "dihydropyridines" ndi "non-dihydropyridines".Minofu yosalala ya mtima ndi mitsempha ya "contractile process" imadalira kulowa kwa ma "extracellular calcium ions" m'maselowa kudzera mu njira zina za ayoni.mosankha amalepheretsa kuyenda kwa ayoni a calcium kudutsa ma cell membranes, njira yomwe imakhudza maselo osalala a minofu kuposa maselo amtima.Zotsatira zoyipa za inotropic (Inotrope), kapena kuchepa kwa myocardial contractility, zitha kudziwika mu vitro.Komabe, zotsatira zotere sizinawonedwe mu zinyama zomwe zimaperekedwa mkati mwa mlingo wovomerezeka wochizira.Kuchuluka kwa calcium mu seramu sikukhudzidwa.M'thupi pH range, ndi ionized compound (pKa = 8.6) yomwe kuyanjana kwake ndi calcium channel receptors kumadziwika ndi kuchuluka kwa ma receptor omwe amamanga malo ogwirizanitsa ndi kupatukana, ndipo kachitidwe kameneka kameneka kamayambitsa kuyambika kwapang'onopang'ono.
ndi peripheral arterial vasodilator yomwe imagwira ntchito mwachindunji pamitsempha yosalala ya mitsempha, zomwe zimapangitsa kuchepa kwa zotumphukira za vascular resistance komanso kuchepa kwa magazi.Njira yeniyeni yomwe imachepetsera angina sikumveka bwino, koma imaganiziridwa kuti ikuphatikizapo zotsatirazi: Kuthamanga kwa angina: Odwala omwe ali ndi angina yogwira ntchito, NORVASC imachepetsa kukana kwathunthu kwa zotumphukira (pambuyo pake) panthawi ya ntchito yamtima pamlingo uliwonse wochita masewera olimbitsa thupi ndikuchepetsa mankhwala kuthamanga, potero kuchepetsa m`mnyewa wamtima mpweya kufunikira.
Poyamba, 5 mg kamodzi patsiku, ndikuwonjezeka mpaka 10 mg kamodzi patsiku.
